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PF-06446846 hydrochloride
CAS No. 1632250-50-0
PF-06446846 hydrochloride ( —— )
产品货号. M33462 CAS No. 1632250-50-0
PF-06446846 hydrochloride 是一种具有口服活性，高选择性前蛋白转化酶枯草杆菌蛋白酶/kexin 9 型 (PCSK9) 的翻译抑制剂。PF-06446846 hydrochloride 可通过诱导核糖体停在密码子 34 周围，从而抑制 PCSK9。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1176 | 有现货 |
|
| 5MG | ￥1825 | 有现货 |
|
| 10MG | ￥2931 | 有现货 |
|
| 25MG | ￥4637 | 有现货 |
|
| 50MG | ￥6631 | 有现货 |
|
| 100MG | ￥8951 | 有现货 |
|
| 500MG | ￥17825 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PF-06446846 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PF-06446846 hydrochloride 是一种具有口服活性，高选择性前蛋白转化酶枯草杆菌蛋白酶/kexin 9 型 (PCSK9) 的翻译抑制剂。PF-06446846 hydrochloride 可通过诱导核糖体停在密码子 34 周围，从而抑制 PCSK9。
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产品描述PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochlorideinhibits PCSK9 by inducing the ribosome to stall around codon 34.
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体外实验PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC50 of 0.3 μM.
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体内实验PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels.Animal Model:Male Sprague-Dawley (Crl:CD [SD] rats, 6-8 wk old at initiation of dosing)Dosage:5, 15, and 50 mg/kg Administration:Oral gavage; daily for 14 daysResult:Lowered plasma PCSK9 in a dose-dependent manner and lowered total cholesterol levels.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number1632250-50-0
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分子量
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分子式C22H20CIN7O.XHCl
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 250 mg/mL (531.52 mM; 超声助溶 ) H2O 中的溶解度 : 100 mg/mL (212.61 mM; 超声助溶)
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SMILESCl.Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-n1nnc2cccnc12
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lintner NG, et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2017 Mar 21;15(3):e2001882.?
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